This study is investigating the effects of combining 2 medications, Varenicline (commonly known as Chantix®) and N-acetylcysteine, on smoking behavior in daily cigarette smokers who are interested in quitting smoking. The study consists of 10 visits over 6 weeks. Smokers must be between the ages of 18 and 55.

The purpose of this study is to explore whether “QuitBuddy”, a quit-smoking app, can improve quit attempt outcomes for those using over-the-counter quit medicine by providing reminders and prompts for the most effective times to take a dose. Participants will also use the app to complete surveys about their smoking use and behaviors outside of the clinic visits. Nicotine replacement therapy (lozenges) will be provided at no cost to assist with the quit attempt as well as ongoing study participation. The study involves 6 visits over the course of 3 months.

Current smokers and nonsmokers are needed for an observational study that is comparing carbon monoxide (CO) monitors. CO monitors are used in smoking research to assess smoking use/behavior by assessing the level of carbon monoxide in a breath sample. The study involves almost daily but brief visits over the course of 2 weeks. There is a total of 10 visits after completing the initial screening visit. No quit attempt is required for smokers.

Current cigarette smokers that are not looking to actively make a quit attempt within 30 days are needed for an observational/nontreatment study to examine how ventilation levels in cigarette filters influences the appeal of the product as well as risk perceptions and the intent to purchase. This study is completed in 2 visits and will involve smoking various cigarettes and completing surveys and questionnaires.

This non-treatment study is looking at the effects of Clavulanic Acid (a drug used in antibiotics) on brain activity with smoking withdrawal. Participants do not need to be looking to quit but must be willing to make a quit attempt during their participation. This study involves 6 visits to the clinic over 2 weeks.

The purpose of this project is to understand how different e-cigarettes influence their likeability and use among current smokers who try using e-cigarettes. Participants will receive an e-cigarette to sample over a three-week period. During this time, they will complete daily electronic diaries and weekly lab visits.

The purpose of this study is to measure changes in smoking behavior during and following sampling of an e-cigarette product. We are testing the effects of one specific e-cigarette (NJoy) on smoking behavior. Neither the tobacco industry nor any e-cigarette manufacturer provides support of any kind to this study. There is no requirement to quit smoking in this study. This study involves 7 phone calls and 4 study visits over 6 months of participation.

In this study we are evaluating a new tool to assist individuals with quitting cigarette smoking. Transcranial magnetic stimulation (TMS) is a non-invasive technique that uses magnetic pulses to temporarily stimulate specific brain areas (without the need for surgery, anesthetic, or other invasive procedures). This treatment study will test whether 10 daily sessions of TMS over the forehead can help decrease smoking rates in treatment-seeking individuals. There are a total of 15 study visits completed over 6-8 weeks of participation.

This study is looking to recruit smokers over the age of 18 that are willing to complete a mandatory 2-day abstinence from smoking. Participants will receive either Rapamycin (also known as Sirolimus, an FDA approved drug for use with transplants) or a placebo to assess potential effects on smoking craving and relapse. This study involves 4 visits over the course of about 3 weeks.

This study examines the use of smoking cues (pictures, videos and objects) to change a person’s interest in smoking. This treatment study does NOT involve the use of study medication. Participants will complete 12 clinic visits over the course of 6 months. Participants must be between 22-65 in order to participate.